Advances in siRNA delivery in cancer therapy

Advances in Lipid Nanoparticles for siRNA Delivery

Technological advances in both siRNA (small interfering RNA) and whole genome sequencing have demonstrated great potential in translating genetic information into siRNA-based drugs to halt the synthesis of most disease-causing proteins. Despite its powerful promises as a drug, siRNA requires a sophisticated delivery vehicle because of its rapid degradation in the circulation, inefficient accumu...

Multifunctional siRNA Delivery System for Cancer Therapy

The rationale for this study is to develop a multifunctional nanomedicine platform for siRNA targeted delivery to cancerous tumors as well as the use of MRI as a non-invasive strategy to monitor the drug therapy outcome. Therefore, we propose a novel multifunctional gene delivery vector by combining the magnetic properties of iron oxide nanoparticles and their ability to package siRNA strands i...

Advances in Targeted Drug Delivery

Recent Developments in Nanoparticle-Based siRNA Delivery for Cancer Therapy

RNA interference (RNAi) is a gene regulation mechanism initiated by RNA molecules that enables sequence-specific gene silencing by promoting degradation of specific mRNAs. Molecular therapy using small interfering RNA (siRNA) has shown great therapeutic potential for diseases caused by abnormal gene overexpression or mutation. The major challenges to application of siRNA therapeutics include th...

Advances in Targeted Drug Delivery